A germaphopic tour director must join forces with an undercover cop in order to catch an antiquities thief hiding among his misfit group of passengers and arrest both them and their client by the time the tour finishes in San Francisco.

SYNOPSIS:

Germaphobe, burnt-out tour “director” (don’t ever call him a “guide”) Curtis Keller has been on the road for weeks doing the same tour over and over, and just wants to go home so he can sleep on a pillow that doesn’t stink like someone else’s hair. However, he gets a rude awakening one morning on the last leg of what he thinks will be his last trip before a well-deserved break. His boss calls and orders him to take over and finish a tour for Jan, a guide who has ditched her group in Arizona. Curtis only accepts after getting a promise that he can take time off afterwards. After a bone-jarring ride in an ancient rust bucket driven by a madman who looks more like an ex-con than a cab driver, he arrives in the desert in the middle of nowhere. He meets what is left of Jan’s misfit group, the rest having rented a car from Enterprise and hightailed it out of there. The remaining group includes: Bossy soccer mom Marilyn and browbeaten dad Tom and their glued to their phones kids Emily and Zach; loud (both in volume and clothes) couple George and Carol; attached at the hip newlyweds Jason and Tiffany; geeky couple Brad and Lisa in matching LL Bean; and elderly, oblivious Brooklynites Max and Ethel.

Way Out West spells out WOW, but Curtis has lost all enthusiasm for his company’s motto. At the first stop, Monument Valley, he meets Tony Wong, a Chinese agent working undercover as a tour guide, who Curtis immediately nails as a total “noob.” They meet up with the guides leading the foreign-language tours and run into them at each stop along the itinerary: soft-spoken Yu Lin, sporty Gisela, exotic Sofia, and melodramatic François. That night at their hotel, Tony tells Curtis who he really is, and that Jan was the victim of foul play. If that weren’t enough, Curtis also has a thief/assassin among his eccentric flock. Jan’s murder is tied to a priceless piece of jade stolen from a Hong Kong museum, and clues lead directly to his group. Curtis can’t believe any of them has the makings of a cat burglar, let alone capable of murder. He thinks his creepy bus driver Lenny probably scared off Jan, and she’s nursing a hangover in Vegas, her favorite tour stop. Tony tries to convince him otherwise to no avail, but gets Curtis to promise that he won’t blow Tony’s cover.

Skeptical Curtis finds a bloody woman’s blouse in the coach toilet, which is the convincing evidence that proves Tony right regarding Jan’s fate, Although they’re both loners used to working on their own, Curtis and Tony must join forces as they try to get to San Francisco without raising the thief’s, or thieves’, suspicions so that both the culprit and their potential client can be caught red-handed and arrested by local police. Curtis hears and sees clues from all his passengers that they could be the guilty party. Along the way, they confront Yu Lin, who turns out to be masquerading as a guide. They don’t find out until the end that she wants the jade for herself to use as leverage to get her boyfriend out of prison. She needs Tony and Curtis gone in order to steal it from Brad and Lisa, the unassuming passengers in Curtis’s group who have it. She sets traps along the way, which leads to dangerous and humorous predicaments, where they are saved by Tony and his martial arts skills, and Curtis armed with his instinct for survival and disinfectant.

Curtis, who starts the journey "jaded” by his passengers and the magnificent scenery he’s seen a zillions times, views both in a new light as the tour progresses. Spectacular and hilarious action scenes play out at each spot. After Monument Valley, they visit the Grand Canyon (where Yu Lin tampers with the helicopter Curtis and Tony are in, and they must make an emergency exit. Curtis lands on a tree and is saved in the nick of time by his bag’s strap catching a branch), the Skywalk (where Yu Lin pushes Tony over the railing, and is rescued by Curtis and Gisela improvising a belt rescue like amateur MacGyvers), and the dangerous Hoover Dam road (where Tony thinks he gets rid of Yu Lin).

In Las Vegas, the boys almost blow Tony’s cover when after a few drinks, things get too cozy between them and Gisela and Sofia, and they wake up in their hotel rooms in their birthday suits. According to Gisela and Sofia, they were perfect gentlemen. What happens in Vegas stays in Vegas... The trip culminates in San Francisco, where they follow Brad and Lisa when they meet with their client, but discover that the jade they have is a fake. Yu Lin is in possession of the real piece. They finally discover her motive, and take her on in one final all-out battle for the jade on a cable car. Yu Lin is arrested. Tony thanks Curtis and congratulates him on his well-deserved break.

Turns out, Curtis gets bored after being home for awhile. Surviving his adventure made him feel alive again, and he misses the excitement. Watching a travel show sparks the travel bug in him once more, and we discover him with a new look and outlook. He and Gisela are rafting guides in the Italian Alps with their passengers Tony, Sofia, François and his boyfriend riding the rapids and having a blast.