The Powerpuff Girls are under attack by Him, Sedusa, The Gang Green Gang and Fuzy Lumpkuns. And also under attack by a new Aku in the form of Mitch Mitchelson. The girls must use their powers to stop all of these new villains.

SYNOPSIS:

After the events of Kids Next Door, The Powerpuff Girls are now living on their own in an apartment in Townsville and they go to community college. However there are a lot of new dark elements as Blossom meets a out-casted teenager name Mitch Mitchelson. And she starts helping him with school. But at the same time, There are a lot of villains that are coming out of the darkness including Him and Sedusa and they want to turn Townsville into a dark living hell and use other villains such as the gang green gang, the communist family name the Smiths, and Fuzy Lumpkins. Him even kills Mitch's grandma and adopts Mitch only to turn him into the new Aku and he kidnaps Miss Bellum and locks her into Him's sckcrapper building in Townsville. The girls start discovering a lot of dark secrets in their city and they have to rescue Miss Bellum. But rescuing has big time consequences as Townsville gets destroyed by a lot of brain washed people that are infected with demon and devil magic caused by Him and they start destroying Townsville and destroying property and burning buildings to the ground as well. The girls are reunited with the professor and he revels to the girls that he is Samurai Jack and he rounds up a lot of other Cartoon Network characters because the situation has gotten very out of hand and now Samurai Jack, The Powerpuff Girls, The Justice Friends, and other characters are now going to fight a lot of anti America, communist and socialist antifa people that are working for Mojo Jo Jo and now have to prepare for another generational American Civil war and not repeat any of the mistakes that happened during the Vietnam war in 1963 when Samurai Jack was fighting Aku in New York City. And new war is a dark and grim continuation of the war the war between Samurai jack and Aku only this time it's Mojo Jo Jo trying to finish what Aku started.

THE POWERPUFF GIRLS: THE RISE OF WAR ( THE 7TH STORY IN THE CARTOON NETWORK CINEMATIC UNIVERISE)